Establishment of visualization system for cancer epigenome with 2C reporter

2015 Fiscal Year Final Research Report

• Project/Area Number: 26830069
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Kyoto University
• Principal Investigator: Semi Katsunori 京都大学, iPS細胞研究所, 研究員 (90633058)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: がん / エピジェネティクス

Outline of Final Research Achievements

Establishment of chimeric mice which were derived from lung cancer model, colon tumor model and OSKM-inducible ESCs. After the induction of tumorigenesis, we observed reporter expression in lung cancer and OSKM-inducible model. Moreover, we examined the expression of transposable element in EWS/ATF1-inducible mouse clear cell sarcoma cell lines. The expression level was increased in the absence of oncogene expression. This phenomenon was also observed in human cancer cells. So, we trying to establish the drug screening system which apply the retrotransposon expression to indicator for oncogene suppression.

Free Research Field

エピジェネティクス