2016 Fiscal Year Final Research Report
Molecular mechanism of the lipid raft-based oncogenic signal transduction
| Project/Area Number |
26830071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | Src / 脂質ラフト / 上皮管腔形成 / 浸潤 |
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| Outline of Final Research Achievements |
The tyrosine kinase Src regulates both normal physiological functions and cancer progression. However, the molecular mechanism of the spatiotemporal regulation of Src is not fully understood. In this study, we identified Rsp1 as a regulator of activated Src in the lipid rafts. In normal cells, Rsp1 coordinately controlled epithelial tubulogenesis through spatiotemporal regulation of the Src signaling pathway. Meanwhile, Rsp1 promoted invasiveness in cancer cells. These findings indicate that Rsp1 controls the diverse functions of Src through the spatiotemporal regulation of activated Src.
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| Free Research Field |
腫瘍生物学
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