2015 Fiscal Year Final Research Report
Understanding metabolic regulation of epithelial-mesenchymal transition
| Project/Area Number |
26830073
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kobe University |
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Principal Investigator |
Irino Yasuhiro 神戸大学, 医学(系)研究科(研究院), 特命助教 (10415565)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 代謝 / がん |
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| Outline of Final Research Achievements |
The epithelial-mesenchymal transition (EMT) contributes cancer progression. Although previous reports suggest that alternations in cell metabolism are characteristic of many tumor cells, the contribution of cancer metabolism to the morphological changes in EMT remains elusive.
To examine the roles for changed metabolism, we analyzed the metabolome of breast cancer cells before and after EMT using a gas-chromatography mass spectrometry. We found that metabolic profiling was dramatically changed during EMT. EMT resulted in increase in pyruvic acid and lactic acid and decrease in phosphoenolpyruvic acid, indicating the activation of glycolysis.
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| Free Research Field |
腫瘍生物学
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