Development of new molecular target therapy for IGF1 signaling pathway in glioma stem cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 26830082
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Keio University
• Principal Investigator: Satoru Osuka 慶應義塾大学, 医学部, 特別研究員(PD) (70724574)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 脳腫瘍幹細胞 / グリオーマ / 放射線抵抗性 / IGF1 / 細胞接着

Outline of Final Research Achievements

Glioblastoma (GBM) is the most aggressive brain tumor in adult. Poor prognosis of patients with GBM is due to glioma stem cells (GSCs) that have characteristics of stem cells, with high chemo- and radio-resistance. In my prior study, we revealed a role for IGF1 signaling activation in the radioresistance of GSCs. In this study, we analyzed the detailed of IGF1 downstream signaling to implicate radioresistance in GSCs.
We found that: (i) adaptation of mouse GSCs to repeated irradiation increases cell-cell adhesion and radioresistance, (ii) recurrent human GBM display an increase in the expression of adhesion-related genes in microarray analysis, (iii) fractionated irradiation induces a gradual upregulation of N-cad in surviving GSCs.

Free Research Field

脳腫瘍