2015 Fiscal Year Final Research Report
analysis of a new endogenous protein in endometrial cancer
| Project/Area Number |
26830084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
|
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| Research Institution | Osaka Medical College |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 子宮内膜細胞 / デコリン / プロゲステロン / ディナゲスト / 細胞周期 |
|---|
| Outline of Final Research Achievements |
Decorin has been shown to be a powerful endogenous tumor repressor acting in a paracrine fashion to limit tumor growth. It was noted that progesterone and dienogest directly induced the binding of the decorin promoter.Progesterone and dienogest also led to significant induced cell cycle arrest via decorin by promoting production of p21. Ｄecorin induced by dienogest appears to play a
crucial role in suppressing endometriosis by exerting anti-proliferative effects and inducing cell cycle arrest via the production of p21 human ectopic endometrial cells and eutopic endometrial stromal cells.
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| Free Research Field |
婦人科腫瘍
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