Identification of a responsible gene for multi step leukemogenesis of ATL by using the panel of ATL-derived cell lines.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26830087
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: INE SHOJI 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 研究員 (80573683)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 成人T細胞白血病 / シグナル伝達

Outline of Final Research Achievements

To identify critical factors for the onset of adult T cell leukemia (ATL), we fractionated the cell population showing high tumor-initiating ability in immune deficient NOG mice from ATL-derived cell lines.These cells also showed the up regulation of AKT and NF-kB signaling, which suggests the possible role of these signal transduction pathways in tumorigenicity of ATL cells. To reveal the responsible genes for up regulation of NF-kB signaling, we conducted functional screening using the NF-kB-reporter cell and could identify unreported genes which can modulate NF-kB signaling.

Free Research Field

血液腫瘍学