2015 Fiscal Year Final Research Report
Analysis of the role of nervous and immune system interactions in development of colon cancer
| Project/Area Number |
26830091
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor biology
|
|---|
| Research Institution | Aichi Cancer Center Research Institute |
|---|
Principal Investigator |
Kajino Rie 愛知県がんセンター(研究所), 分子病態学部, 研究員 (20633184)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 大腸がん / 免疫 / 神経 |
|---|
| Outline of Final Research Achievements |
We investigated the involvement of nervous and immune system interactions in development of colon cancer using a mouse model for colorectal and intestinal cancer.
MyD88 plays a central role in innate immunity. Loss of MyD88 function in intestinal epithelial cells, induced by tamoxifen administration, leaded to a reduction of the number of intestinal tumors in MyD88FL/FL; Apc; Villin-CreERT2 compound mutant mice. In addition, we found that several neuropeptide levels were changed in tumors developed in Apc mutant mice. Among them, expressions of five neuropeptides were affected by stimulation of mouse intestinal organoids with several cytokines. These results suggest that the possible involvement of nervous and immune system interactions in development of colon cancer.
|
| Free Research Field |
腫瘍生物学
|
