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2015 Fiscal Year Final Research Report

Exploration of mechanism of drug resisitance in cancer acidic condition and development of novel therapeutic drug

Research Project

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Project/Area Number 26830108
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor therapeutics
Research InstitutionThe University of Tokushima

Principal Investigator

NAKAMURA Shingen  徳島大学, 大学病院, 助教 (10511321)

Project Period (FY) 2014-04-01 – 2016-03-31
Keywordsがん酸性環境 / pim2
Outline of Final Research Achievements

Tumor acidity has been known to confer drug resistance in cancers, however, therapeutic drug targetting tumor acidic microenvironment have not been developed. Pim2 was highly upregulated in myeloma cells, and SIRT1, BCRP, monocarbonic transporter were upregulated in acidic condition. Pim inhibitor improved all of these change. We explored compound library in faculty of pharmaceutical sciences,and found cucurbitacinB was one of a candidates of therapeutic drugs for targeting tumor acidic condition.

Free Research Field

がん薬物療法学

URL: 

Published: 2017-05-10  

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