2016 Fiscal Year Final Research Report
Development of cancer therapy for chromatin remodeling deficient cancer
| Project/Area Number |
26830122
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Ogiwara Hideaki 国立研究開発法人国立がん研究センター, 研究所, 研究員 (40568953)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | ARID1A |
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| Outline of Final Research Achievements |
The SWI/SNF chromatin remodeling gene ARID1A is frequently aberrant in ovarian and other many common cancers without effective therapies. A druggable vulnerability of ARID1A-deficient cancers would be useful for treating such cancers. Here, we show that compound X preferentially decrease survival of ARID1A-deficient cells and induce apoptosis in ARID1A-deficient cells.
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| Free Research Field |
腫瘍治療学
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