2015 Fiscal Year Final Research Report
Biochemical analysis of mRNA quality control in S. cerevisiae
| Project/Area Number |
26840002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | リボソーム / 品質管理 / 新生鎖 |
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| Outline of Final Research Achievements |
Aberrant and non-functional mRNA are furequently generated in the cell due to error during mRNA biogenesis process. Co-translational quality control system monitors translation and immediately eliminates aberrant or non-functional mRNA and nascent product before translation is complete. Translation of poly(A) tail is one of the aborted translation in the cell, and generates poly-lysine peptide, inducing translation arrest and rapidly degradation of nascent peptides. However, the mechanism underlaying recognition such an abnormal translation remain poorly understood. In this project, I have identified novel factors involved in the recognition of aborted translation and induction of quality control system to remove generating non-functional nascent products.
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| Free Research Field |
分子生物学
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