2015 Fiscal Year Final Research Report
Structural basis of Archaeal ESCRT complex
| Project/Area Number |
26840018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Structural biochemistry
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| Research Institution | University of Toyama |
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Principal Investigator |
OBITA TAKAYUKI 富山大学, 大学院医学薬学研究部(薬学), 准教授 (30578696)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 細胞質分裂 / ESCRT / 構造生物学 |
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| Outline of Final Research Achievements |
We have determined the structure of two archaeal ESCRT-II like proteins, one is from S. acidocaldarius and the other is from S. solfataricus. Both proteins have winged-helix domain fold with additional two helices, but the structures are quite different from human ESCRT-II proteins. We have also showed that the archaeal ESCRT-II like proteins bound to DNA. These results show that ESCRT proteins may have unique roles in archaea.
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| Free Research Field |
構造生物学
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