2015 Fiscal Year Final Research Report
Regulation of gene transcription by the voltage gated calcium channels activation.
| Project/Area Number |
26840032
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
Kurokawa Tatsuki 京都大学, 工学(系)研究科(研究院), 助教 (40527701)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | イオンチャネル / カルシウム / 膜電位 |
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| Outline of Final Research Achievements |
Recently, our laboratory showed a new signaling pathway that the voltage gated calcium channels (VGCC) β4 subunit accumulates in the nucleus and acquires a gene regulatory function under membrane depolarization (Tadmouri et al EMBO J., 2012). These findings demonstrate that an intact VGCC subunit acts as a repressor recruiting platform to control neuronal gene expression. The aim of this project is to resolve the mechanism of a new and important signaling pathway that links the VGCC activation to gene transcription.
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| Free Research Field |
生化学
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