Analysis of HTLV-1 Tax-induced IKK activation pathway

2015 Fiscal Year Final Research Report

• Project/Area Number: 26840062
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cell biology
• Research Institution: The University of Tokyo
• Principal Investigator: SHIBATA Yuri 東京大学, 医科学研究所, 助教 (20722573)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: HTLV-1 Tax / ATL / ユビキチン修飾 / NF-kappaB

Outline of Final Research Achievements

HTLV-1 Tax-induced persistent activation of transcription factor NF-κB is crucial for cell immortalization and the onset of ATL. Here, we analyzed the precise mechanism underlying Tax-induced NF-κB activation pathway. We found that Tax induces hybrid ubiquitin chains, which enhance the formation of macromolecular complex of active IKK complex.

Free Research Field

生物科学