Synthetic study of novel antibiotics derived from natural products using cluster effect

2015 Fiscal Year Final Research Report

• Project/Area Number: 26850074
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bioorganic chemistry
• Research Institution: Tohoku University (2015); National Institute of Advanced Industrial Science and Technology (2014)
• Principal Investigator: ENOMOTO Masaru 東北大学, (連合)農学研究科(研究院), 准教授 (90546342)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: クラスター効果 / 天然物 / 金ナノ粒子 / 抗菌物質 / ケモセンサー

Outline of Final Research Achievements

Multivalent interaction that enhances affinity between proteins and ligands is called a cluster effect. We evaluated the binding affinity and antifungal activity of PRM-AuNPs, which was synthesized by functionalizing gold nanoparticles (AuNPs) with pradimicin (PRM), antifungal and anti-HIV natural product. Consequently, the binding affinity of PRM-AuNPs to mannose (Man) was found to increased ten times as strong as the case of PRM although the antifungal activity of PRM-AuNPs was slightly decreased. Moreover, by making use of the distance-dependent optical properties of AuNPs as well as the Man-specific binding ability of PRM, we have developed a chemosensor that was capable of recognizing mannose residues in oligosaccharides.

Free Research Field

天然物化学