Analysis of neuropeptide-receptor signalings that control reproductive nerve center in domestic ruminants

2015 Fiscal Year Final Research Report

• Project/Area Number: 26850168
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Animal production science
• Research Institution: Nagoya University
• Principal Investigator: Matsuda Fuko 名古屋大学, 生命農学研究科, 准教授 (10608855)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ヤギ / 視床下部 / 不死化神経細胞株 / KNDyニューロン

Outline of Final Research Achievements

We aimed to clarify the neuroendocrine mechanisms that control the reproductive function at cellular level using goats, a good model for ruminants. We focused on KNDy neurons located in hypothalamus, which is thought to be the master regulator of reproductive function and known to secrete 3 neuropeptides, kisspeptin, neurokinin B and dynorphin A. First, we determined the localization of dynorphin receptors in goat hypothalamus. Next, we established an immortalized cell line derived from a goat KNDy neuron. The cell line will be useful to analyze how KNDy neurons are regulated at cellular levels.

Free Research Field

家畜繁殖学