Synthetic studies on polycyclic alkaloids based on development of cascade reactions

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860004
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Chemical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: Ueda Hirofumi 東北大学, 薬学研究科, 助教 (50581279)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 有機化学 / 薬学 / 生物活性天然物 / 全合成 / アルカロイド / カスケード反応 / キノリン / ステモナアルカロイド

Outline of Final Research Achievements

We undertook synthetic studies on highly fused polycyclic alkaloids such as isoschizogamine, stenine and its congeners via original cascade cyclization reactions. Thus, we developed synthetic methodologies for concise constructions of highly functinalized quinoline skeleton and tricyclic skeleton including pyrroloazepine moiety, which are found in natural compounds. Furthermore, we achieved an asymmetric total synthesis of (-)-isoschizogamine by using the synthetic intermediate derived via the cascade cyclization reaction.

Free Research Field

有機合成化学