2015 Fiscal Year Final Research Report
Design and synthesis of metallodrugs based on self-assembly systems
| Project/Area Number |
26860016
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | がん治療薬 / イリジウム錯体 / カチオン性ペプチド / 細胞死 / 金属錯体 |
|---|
| Outline of Final Research Achievements |
We report on the design and synthesis of amphiphilic and luminescent tris-cyclometalated Ir complexes that work as inducers and detectors of cell death. Ir complexes containing cationic peptides such as a KKGG sequence and alkyl chain linkers of adequate length (C6 and C8) exhibit considerable cytotoxicity against Jurkat cells. Mechanistic studies suggest that Ir complexes containing the KKGG peptide interact with anionic molecules on the cell surface and/or membrane receptors to trigger the Ca2+ dependent pathway and intracellular Ca2+ response, resulting in necrosis accompanied by membrane disruption.
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| Free Research Field |
生物有機化学、錯体化学
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