2016 Fiscal Year Final Research Report
Development of polypodna based dendritic nano-sized DDS
| Project/Area Number |
26860021
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Setsunan University |
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Principal Investigator |
Mohri Kohta 摂南大学, 薬学部, 助教 (30723697)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 核酸 / ナノ粒子 / DDS / CpGモチーフ |
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| Outline of Final Research Achievements |
To increase the therapeutic potency of immunostimulatory CpG DNA, we tried to develop polypod-like structured DNA, or polypodna based dendritic nano-sized DDS. We succeeded in constructing dendritic-like DNA (DL-DNA) by connecting polypodnas through their adhesive terminal ends, but not ligating with enzymatic reaction. Furthermore, we found that DL-DNA was efficiently taken up by immune cells, which dramatically increased the cytokine release by CpG DNA. Thus, we have shown that the DL-DNA developed by this approach, can be an useful nano-sized DDS for increasing the potency of nucleic acid drugs.
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| Free Research Field |
薬学
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