Establishment of mechanical spheronization technique of drug crystals for development of fine pharmaceutical products with controlled release characteristics

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860028
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: Meijo University
• Principal Investigator: Keita Kondo 名城大学, 薬学部, 助教 (90710913)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 乾式複合化 / 球形化 / 医薬品薬物 / 粒子強度 / 付着凝集性 / 被覆造粒 / 凝集造粒

Outline of Final Research Achievements

In this study, we elucidated spheronization mechanism of drug crystals through extremely-high shearing using a mechanical powder processor. In addition, we investigated the relationships between spheronization and mechanical properties of drug crystals. Strong crystals were mechanically spheronized by layering granulation of relatively large particles resulted from partial destruction of drug crystals. Meanwhile, weak crystals became spherical particles by agglomeration of fine powder generated through pulverization of drug crystals. Low-cohesive powder did not undergo layering granulation or powder agglomeration not to be spheronized. Therefore, we concluded that the success or failure of mechanical spheronization is determined by cohesiveness of drug powder.

Free Research Field

製剤学