2016 Fiscal Year Final Research Report
Research on fertility improvement using cyclodextrins
| Project/Area Number |
26860039
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
Takeo Toru 熊本大学, 生命資源研究・支援センター, 講師 (10517014)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 不妊 / シクロデキストリン / 精子 / 受精能獲得 / コレステロール / リン脂質 / 生体膜 / 体外受精 |
|---|
| Outline of Final Research Achievements |
The number of subfertile and infertile patients is increasing in advanced countries. However, there is no innovative solution to improve their fertility. In this study, we examined the effect of cyclodextrins on the functions of mouse sperm. Methyl-beta-cyclodextrin enhanced fertility and promoted acrosome reaction and hyperactivation by enhancing membrane fluidity with the reduction of cholesterol in sperm membrane. Dimethyl-alpha-cyclodextrin also increased fertility of sperm by induction of lipids efflux from sperm membrane. These results suggest that cyclodextrins is applicable as fertility activator in the in vitro fertilization.
|
| Free Research Field |
生物系薬学、発生生物学、生殖工学
|
