2015 Fiscal Year Final Research Report
The functional regulation of Reelin and its application to drug discovery
| Project/Area Number |
26860043
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
Kohno Takao 名古屋市立大学, 薬学研究科(研究院), 助教 (70581742)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 脳 / リーリン / プロテアーゼ |
|---|
| Outline of Final Research Achievements |
Reelin is glycoprotein that is essential for normal brain formation and function. The hypofunction of Reelin is related to neuropsychiatric disorders.
We found that Reelin is cleaved within its C-terminal region and this cleavage regulates position and dendrite development of upper-layer neurons. Furthermore, we found the upregulation of Reelin activity by inhibition of Reelin cleavage does not affect the neuronal layer formation in embryonic stages.
|
| Free Research Field |
分子神経生物
|
