2015 Fiscal Year Final Research Report
Identification of novel phospholipid metabolic pathway which is essential for somatic cell survival in C. elegans
| Project/Area Number |
26860045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
MAEBAYASHI KANA
SHIMOGOORI MOE
TAKAHASHI ASUKA
TOMINAGA KEITA
MISAWA KAORI
HIROYOSI RYO
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | カルジオリピン / ミトコンドリア / 脂質 / 線虫 / 生殖細胞 / 体細胞 |
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| Outline of Final Research Achievements |
Cardiolipin (CL) is an acidic phospholipid specifically localized in mitochondrial inner membrane. By interacting with various mitochondrial proteins, CL contributes to the maintenance of the structure and function of those mitochondrial proteins. We have demonstrated that deletion of CL synthase (crls-1) selectively caused abnormal mitochondrial function and morphology in germ cells but not in somatic cells. In this study, by a forward genetic screening, we isolated a gene deletion mutant that shows synthetic lethal phenotype in combination with the crls-1 deletion mutant allele. This is the first study to suggest the existence of a novel CL synthetic pathway or a phospholipid that compensate the function of CL in C. elegans.
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| Free Research Field |
医歯薬学
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