2015 Fiscal Year Final Research Report
Molecular basis of SIGIRR expression and regulatory function in Cystic Fibrosis and its therapeutic approach
| Project/Area Number |
26860062
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
SHUTO Keiko 崇城大学, 薬学部, 助教 (70510692)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | CF / SIGIRR |
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| Outline of Final Research Achievements |
Cystic Fibrosis（CF）is an autosomal recessive inherited disorder characterized by chronic airway inflammation, which is partially due to the defective expression of negative regulators of TLRs signaling. In this study, we compared the expression levels of SIGIRR, a negative regulator of TLRs signaling, between normal (non-CF) and CF airway epithelial cells. Our data indicated that the cell surface level of SIGIRR was clearly decreased in CF compared with normal, although there was no difference regarding SIGIRR expressions at whole cell levels. This result suggests that SIGIRR is inefficiently or unstably expressed on CF cell surface compared with normal.
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| Free Research Field |
薬理学、細胞生物学
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