2015 Fiscal Year Final Research Report
Elucidation of the chiral recognition mechanism using tea gallate-type catechins
| Project/Area Number |
26860074
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Natural medicines
|
|---|
| Research Institution | Fukuyama University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 不斉認識 / エピガロカテキン-3-O-ガレート（EGCg） / X線結晶構造解析 / NMR / ジケトピペラジン / プロプラノロール |
|---|
| Outline of Final Research Achievements |
Enantiomer, which is relationship between the right hand and the left hand, is known to be difficult to discern and separate them because physical properties are the same. In our previous study, it have been revealed that the tea major compound (-)-epigallocatechin-3-O-gallate (EGCg) captures many substances including caffeine. These results led to the idea that EGCg may be available as a new optical resolving agent for natural products and medicines. Chiral recognition of EGCg is investigated using diketopiperazine cyclo(L-Pro-Gly), cyclo(D-Pro-Gly) and sympathetic β-receptor blocker (R)-propranolol, (S)-propranolol, and we reveal that EGCg can discern these enantiomers.
|
| Free Research Field |
天然物有機化学
|
