Development of G-quadruplex stabilizing agent for growth inhibition of cancer stem cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860077
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Saitama University
• Principal Investigator: IIDA Keisuke 埼玉大学, 理工学研究科, 研究支援者 (70719773)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: がん幹細胞 / グアニン四重鎖 / ケミカルバイオロジー / G4リガンド

Outline of Final Research Achievements

Cancer stem cells (CSCs) are thought to contribute to tumor recurrence and metastasis in many cancers. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour CSCs behind, which might be an important mechanism of resistance. Therefore, effective drug against CSCs are important for cancer therapy. Recently, stabilization of G-quadruplex, non-nanonical DNA structure, is considered to exerts an antitumor activity.
In this project, we described effect of G-quadruplex stabilizing small molecules (G4 ligands) for CSCs. With G4 ligands, we found a growth inhibitory activity against CSCs through DNA damage responce in vitro. And antitumor activities were also abserved in vivo.

Free Research Field

ケミカルバイオロジー