Understanding of the molecular mechanism for the nuclear receptor PXR-mediated regulation of immune/inflammatory responses

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860095
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: Kodama Susumu 東北大学, 薬学研究科, 助教 (20621460)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 核内受容体 / 異物応答 / 免疫応答 / 炎症 / シグナル伝達

Outline of Final Research Achievements

The xenobiotic-sensing nuclear receptor PXR is well-known to play important roles in drug/xenobiotic clearance and hepatic energy metabolism. Recent studies have revealed that PXR also has a role in the regulation of immune/inflammatory responses. However, the precise details are still not fully understood. In this study, we have investigated the molecular mechanism underlying PXR-mediated regulation of immune/inflammatory responses using an in vivo mouse model of immune-mediated liver injury and in vitro cell-based experimental models. Our findings will provide us with useful information to investigate how PXR immune/inflammatory responses.

Free Research Field

衛生化学