Identification of responsible factors of dosing time-dependent effects of cisplatin

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: University of Toyama
• Principal Investigator: Okazaki Fumiyasu 富山大学, 大学院医学薬学研究部(薬学), 助教 (20610348)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 時間薬理 / 体内時計

Outline of Final Research Achievements

Previous reports suggested that chronomodulated chemotherapy using cisplatin improve anticancer effects, but the responsible factors remain unclear in pharmacokinetics and pharmacodynamics study. The purpose of this study is to identify the responsible factors of dosing time-dependent effects of cisplatin. SPT16, which dimerizes with SSRP1 involved in cisplatin resistance, influences dosing time-dependent effects of cisplatin in pharmacodynamics study. On the other hand, the pharmacokinetics study showed no significant difference. This study suggested that pharmacodynamics factors influence dosing time-dependent effects of cisplatin, and identified the responsible factor to determine the property dosing time of cisplatin.

Free Research Field

時間薬理