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2015 Fiscal Year Final Research Report

Correlation analysis between glycosylation and the efficacy of antibody preparation in human blood

Research Project

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Project/Area Number 26860102
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionKyoto University

Principal Investigator

TSUDA Masahiro  京都大学, 薬学研究科(研究院), 講師 (10726813)

Project Period (FY) 2014-04-01 – 2016-03-31
Keywords抗体 / 糖鎖 / 癌 / 質量分析 / バイオテクノロジー / 薬物動態 / 血中濃度 / 翻訳後修飾
Outline of Final Research Achievements


In current study, we analyzed the carbohydrate structure of anti-CD20 monoclonal antibody rituximab to evaluate effect of glycosylation on the efficacy and the pharmacokinetics of antibody preparation. Several glycan species were identified in rituximab. The relative content of glycoforms changed in a time-dependent mannar. These changes affected to pharmacokinetics of rituximab. In conclusion, we obtained novel findings in the role of carbohydrate of rituximab.

Free Research Field

医療薬剤学

URL: 

Published: 2017-05-10  

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