2016 Fiscal Year Final Research Report
Effect of valproic acid on radiation-induced oral mucositis
| Project/Area Number |
26860106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Ehime University |
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Principal Investigator |
TANAKA AKIHIRO 愛媛大学, 医学部附属病院, 准教授 (50527562)
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| Research Collaborator |
Watanabe shinichi 愛媛大学, 医学部附属病院, 薬剤師
Sumikawa Satomi 愛媛大学, 医学部附属病院, 薬剤師
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 放射線誘発口腔粘膜障害 |
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| Outline of Final Research Achievements |
Oral mucositis, a side effect of cancer radiotherapy, occurs primarily during head and neck radiotherapy, causing severe mucosal damage from the oral cavity to the pharynx. However, there is currently no effective therapeutic agent. In our study, it was suggested that sodium valproate as an antiepileptic drug and having HDAC inhibition may be useful for radiation induced oral mucosal disorders.
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| Free Research Field |
医療薬学
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