2015 Fiscal Year Final Research Report
Evaluation for change in drug distribution under hypothermia for optimization of medication
| Project/Area Number |
26860108
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
MIYAMOTO Hirotaka 長崎大学, 医歯薬学総合研究科(薬学系), 助教 (20619481)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 低体温療法 / CYP3A2 / タンパク結合 |
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| Outline of Final Research Achievements |
We have evaluated the pharmacokinetics of midazolam in rats under hypothermia. The plasma concentration of midazolam was increased under hypothermia. However, brain and liver concentration of midazolam did not change under hypothermia. This result suggest the distribution of midazolam was inhibited under hypothermia. We evaluated the protein binding of midazolam in rat serum. The free fraction of midazolam was significantly decreased compared to normal condition.
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| Free Research Field |
薬物動態
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