Approach to new therapeutic strategy against pancreatic cancer by targeting lipid metabolism

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860115
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Yokohama College of Pharmacy
• Principal Investigator: Nishi Koji 横浜薬科大学, 薬学部, 講師 (00398249)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 膵癌 / 脂質代謝 / アポトーシス

Outline of Final Research Achievements

In this study, we investigated the effects of various lipid metabolism inhibitors on proliferation and viability of human pancreatic cancer cells for developing new therapeutic strategy. In used inhibitors, inhibitors to fatty acid synthesis (TOFA, Celurenin, Irgasan) especially showed the remarkable induction of apoptosis and suppression of proliferation. This result indicates that the pathway of fatty acid synthesis is very important for pancreatic cancer cells. On the other hand, these inhibitors did not showed such effects only to PANC1 cell. These result suggest that inhibition of fatty acid synthesis is partially critical to pancreatic cancer cells and can be effective target for chemical therapy.

Free Research Field

分子薬物動態学