2015 Fiscal Year Final Research Report
Development of anti-diabetic nephropathy drug targeting for transglutaminase
| Project/Area Number |
26860118
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
|
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| Research Institution | Meijo University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 終末糖化産物 / トランスグルタミナーゼ2 |
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| Outline of Final Research Achievements |
In the present study, we investigated the mechanism of increasing the expression of transglutaminase 2 (TG2) induced by advanced glycation endproducts (AGEs). In human renal tubular cells, we elucidated that AGEs increased the expression of TG2 via activation of NF-κb. This increasing was inhibited by inhibitor of receptor for AGEs (RAGE). These results suggested that AGEs binds to RAGE and increases the expression of TG2 via activation of NF-κb.
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| Free Research Field |
医療系薬学
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