2015 Fiscal Year Final Research Report
Development the database of taste interaction between drug and food/drinks for pediatric patient
| Project/Area Number |
26860120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 苦味 / 味覚センサ |
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| Outline of Final Research Achievements |
We classified the bitterness or astringency of drugs using taste sensor SA402B. Principal component analysis for taste sensor output of drugs (0.1, 0.3, 1.0 mM) was carried out and the result was represented in map. X-axis and Y-axis were thought to indicate bitterness and astringency respectively. It was estimated that amitriptyline hydrochloride and imipramine hydrochloride represent strong bitterness, while amlodipine besilate, diphenhydramine hydrochloride and donepezil hydrochloride also represent strong astringency. The bitterness of drugs was suppressed by chlorogenic acid. Correlation between bitterness inhibition rate and drug-chlorogenic acid interaction parameter suggested that the interaction between drug and chlorogenic acid contributes to suppressing the bitterness of drug.
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| Free Research Field |
医療薬学
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