Pharmacokinetics and clinical effectiveness of new antiepileptic drugs in patients with refractory epilepsy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860123
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
• Principal Investigator: Yamamoto Yoshiaki 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, その他 (60596245)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: てんかん / 薬物相互作用 / 血中濃度モニタリング

Outline of Final Research Achievements

This study identified factors affecting the pharmacokinetics of new antiepileptic drugs (AEDs) and evaluated the therapeutic concentration range of AEDs. We analyzed 1,653 plasma concentrations of lamotrigine and 1,217 plasma concentrations of topiramate. The concentration to dose ratio as the plasma concentration divided by the weight-adjusted dose was used as a pharmacokinetic parameter. Concomitant use of hepatic enzyme inducers (phenytoin, phenobarbital, and carbamazepine) markedly reduced the plasma concentrations and can could impair decrease its antiepileptic effect.

Free Research Field

医療薬学