2015 Fiscal Year Final Research Report
Involvement of mitochondrial dynamics in brain development and pathogenesis of psychiatric disorders
| Project/Area Number |
26860133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | ミトコンドリア / 脳発達 / 精神疾患 / SUMO化 |
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| Outline of Final Research Achievements |
In this study, we focused on mitochondrial dynamics and observed the effects of the dynamics on brain development and psychiatric disorders. As results, we found interaction between the mitochondrial molecule and the molecule in endoplasmic reticulum, and also revealed that the interaction is important to regulate mitochondrial morphology and function. On the other hand, we observed SUMOylation, which has been reported to have important roles in brain function and mitochondrial function. We identified some potential SUMOylated proteins and studied the effect of SUMOylation on the proteins.
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| Free Research Field |
神経科学・神経解剖学
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