2016 Fiscal Year Final Research Report
The role of nuclear structure and an epigenetic switch in spermatogonial stem cell differentiation
| Project/Area Number |
26860137
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Research Collaborator |
ITOH Takashi 九州大学, 大学院医学研究院, 教授 (90201326)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 生殖細胞 / エピジェネティクス / ヒストン修飾 / 幹細胞 |
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| Outline of Final Research Achievements |
It is well established that long-term spermatogenesis in mammals is supported by spermatogonial stem cells (SSCs). However, the molecular mechanisms governing SSC maintenance and differentiation is poorly understood. This study focused on dynamic changes in nuclear structure and epigenetic status that occur during SSC differentiation. These changes are important for gene expression programs and hence may greatly contribute to the conversion of cellular characteristics as SSCs differentiate. To identify the epigenetic changes in more detail, SSCs and progenitor cells were sorted and the global epigenetic status of each cell population was analyzed.
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| Free Research Field |
医歯薬学
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