2015 Fiscal Year Final Research Report
Immunohistological analysis of autoimmune disease caused by dysfunction of thymic epithelial cells
| Project/Area Number |
26860138
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 胸腺上皮細胞 / 免疫寛容 / T細胞分化 / 胸腺 / 自己免疫 |
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| Outline of Final Research Achievements |
Thymic epithelial cells had been mainly investigated in mice, and identified with keratin expression pattern and biding to lectin. Studying whether this patterns are common between species of not, we immunohistochemistrically stained thymi of mice and rats with already-known methods and newly produced antibody ED18, ED19, and ED21. As a result, medullary thymic epithelial cells were revealed to consist of two subsets, as we named mTEC1 and mTEC2. Binding to lectin and functional molecules were dominant in mTEC1. We also revealed that mTEC1 diminish mainly in cyclosporine A administered rats.
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| Free Research Field |
解剖学
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