Analysis of lipid mediator signaling that increases hyaluronic acid synthesis and the effect of lipid mediator on cell senescence

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860144
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Ochanomizu University
• Principal Investigator: GOTOH Mari お茶の水女子大学, ヒューマンライフイノベーション研究所, 特任准教授 (80467050)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ヒアルロン酸 / 環状ホスファチジン酸 / 繊維芽細胞 / 老化

Outline of Final Research Achievements

We have found that cyclic phosphatidic acid (cPA) has the function of promoting hyaluronic acid production on skin fibroblasts and synoviocyte. In this research project, we revealed that the expression of hyaluronan synthase 2 messenger RNA and protein is up-regulated by cPA treatment.
In addition, we clarified the mRNA expression of hyaluronic acid-related proteins in human skin fibroblasts from donors of various ages (range, 0.7-69 years). As a result, it was revealed that the exertion of hyaluronan synthase did not decrease also in aged cells.

Free Research Field

脂質生化学、細胞生物学