2015 Fiscal Year Final Research Report
Physiological and pathophysiological roles of casein kinase 2 in the regulation of cardiac L-type Ca channels
| Project/Area Number |
26860145
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | Ｌ型カルシウムチャネル / 心筋 / タンパク質リン酸化酵素 / 心筋興奮収縮連関 / アンジオテンシンⅡ |
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| Outline of Final Research Achievements |
CaV1.2 L-type Ca2+ channels (LTCC) play an essential role in cardiac excitation-contraction coupling. We recently found that LTCC activity is regulated by casein kinase 2 (CK2) α’β in immature cardiac myocytes. Here, we examined the molecular mechanism underlying the regulation of LTCC activity by CK2α’β. In this study, we revealed that CK2α’β determines LTCC activity through phosphorylating threonine 1704 of CaV1.2, and that angiotensin II strongly activates LTCC through AT1 receptor/β-arrestin2/Src/CK2α’β in immature but not adult cardiac myocytes.
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| Free Research Field |
イオンチャネルの分子生理・薬理学
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