Imaging analyses for activated platelets' surface to initiate blood coagulation both in in-vivo and in-vitro systems.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860146
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Brzoska Tomasz 浜松医科大学, 医学部, 特任研究員 (80707000)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: Fibrinolysis / Coagulation / Plasminogen / Platelet

Outline of Final Research Achievements

Contribution of activated platelets on the initiation and amplification of coagulation cascade, fibrin formation as well as its lysis was analyzed. PS exposing platelets appeared the initiation sites of both the activation of coagulation cascade and fibrin formation. We also found that plasminogen binds to PS exposing platelets which then initiated fibrinolysis as starting points. These seem important to quickly dissolve generated excess amounts of thrombi in order to keep vascular patency.

Free Research Field

血液凝固・線溶