2015 Fiscal Year Final Research Report
Investigation on the involvement of purinergic signaling in the mechanism of photoaging
Project/Area Number |
26860147
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
General physiology
|
Research Institution | Kitasato University |
Principal Investigator |
KAWANO AYUMI 北里大学, 薬学部, 助教 (30631634)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | UVA / ケラチノサイト / ATP / サイトカイン / 分化 |
Outline of Final Research Achievements |
The initiation of inflammatory response and dyskeratosis by UVA irradiation has large impact on photoaging. In this study, I examined the involvement of ATP in the production of cytokines and abnormal differentiation of UVA-irradiated keratinocytes. The concentration of extracellular ATP was transiently increased after UVA irradiation. UVA induced the production of cytokines (IL-1α, IL-6 and IL-8), and changed the expression of differentiation markers, but these UVA-induced cellular responses were suppressed by pretreatment of apyrase and P2 antagonist. These results showed that ATP might be a key player in the onset of UVA-irradiation-induced photoaging.
|
Free Research Field |
医歯薬学
|