2015 Fiscal Year Final Research Report
Role of fibrinolytic system in bone regeneration impaired by diabetes
| Project/Area Number |
26860152
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
|
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| Research Institution | Kinki University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 糖尿病 / 骨再生 / 線溶系 |
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| Outline of Final Research Achievements |
The present study examined the role of plasminogen activator inhibitor-1 (PAI-1), a principal inhibitor of fibrinolysis, in the impairment of bone repair induced by diabetes using streptozotocin-induced type 1 diabetic mice. Streptozotocin treatment impaired the bone repair and osteogenesis in femur of diabetic female mice, whereas PAI-1 deficiency improved them in diabetic female mice. Our findings suggest that PAI-1 is involved in bone repair and regeneration impaired by diabetes in mice.
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| Free Research Field |
生理学、病態生理学
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