Development of chronic muscle pain model and understanding of pathological condition by using optogenetics

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860158
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Nagoya University
• Principal Investigator: HAYASHI KOEI 名古屋大学, 環境医学研究所, 研究員 (00579592)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 慢性筋痛症 / 光遺伝学 / 筋硬結 / チャネルロドプシン2

Outline of Final Research Achievements

We tried to develop a chronic muscle pain model with taut band and understand a pathological condition by using optogenetics. Light-stimulation of skeletal muscle expressing the light-sensitive channel Channelrhodopsin-2 (ChR2) evoked tetanic contractions. Light-stimulation exposed directly to the muscle evoked larger tetanic contractions compare with exposed through the skin.

Free Research Field

疼痛学