2015 Fiscal Year Final Research Report
Identification of age-related molecules in the circadian clock
| Project/Area Number |
26860160
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 加齢 / 生体リズム / 睡眠障害 / 視交叉上核 |
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| Outline of Final Research Achievements |
With age, humans experience decreased duration and quality of sleep. While our group reported an age-related decline of the neuronal activity rhythms in the master circadian clock in the suprachiasmatic nucleus (SCN) of hypothalamus (Nakamura et al., J. Neurosci. 2011), the cellular mechanism was unclear. In the present study, we demonstrated an effect of aging at the cellular level. This shows that the neural connections between SCN cells are weakened (Nakamura et al., eNeuro 2015). Furthermore, our group reported that infertility symptoms accompanying aging are caused by which a light environment is incompatible with the biological clock (Takasu et al., Cell Rep. 2015). The result of the present research study, that “mismatch between the light environment and the internal clock promotes aging of the biological clock” shows proper amounts of daytime light are important for age-related changes in female reproductive functioning and older individuals’ physiological functioning.
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| Free Research Field |
時間生物学
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