2015 Fiscal Year Final Research Report
Involvment of ubiquitin-proteasome system in the pathophsiology of depression
| Project/Area Number |
26860175
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Meijo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | うつ / ユビキチン化 / セロトニントランスポーター / MAGE-D1 / ストレスモデル |
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| Outline of Final Research Achievements |
Here, I clarified involvement of the ubiquitin-proteasome system in the depression by the crosstalk between basic and clinical researches. In the basic research, different expression changes of serotonin transporter and melanoma antigen gene-D1 (MAGE-D1) is observed between social defeat stress and isolation stress during childhood. The behavioral changes by stress responsiveness in the MAGE-D1 knockout mouse were also different between these stresses. Ubiquitin-related genes were changed by isolation stress during childhood. In the clinical research, the ubiquitinated serotonin transporter levels in the platelet was decreased in the patient with the physical disease associated with depression.
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| Free Research Field |
神経精神薬理
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