2015 Fiscal Year Final Research Report
Analysis of Tumorigenesis and Malignant Transformation Induced by Aberrant Ral Signaling
| Project/Area Number |
26860181
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | Ral / 低分子量GTP結合蛋白質 / Ras / RalGAP / 癌 |
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| Outline of Final Research Achievements |
Ral proteins are members of the Ras superfamily of small GTP-binding proteins that regulate many cellular processes including proliferation, survival, membrane traffic, and cytoskeletal reorganization. Accumulating evidence suggests that Ral is essential for human tumorigenesis and tumor progression. However, its molecular mechanism is largely unknown. In this study we purified and identified novel effector proteins of Ral that may regulate tumorigenesis, invasion, and metastasis.
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| Free Research Field |
生化学
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