Bone-derived factors that act in accordance to bone condition

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860183
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Hokkaido University (2016); The University of Tokyo (2014-2015)
• Principal Investigator: Sumiya Eriko 北海道大学, 遺伝子病制御研究所, 助教 (50724754)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨分泌因子 / 骨芽細胞

Outline of Final Research Achievements

The aim of this study was to identify bone-derived factor(s) that affect the body and to examine whether the effect was related to the condition of the bone (e.g. sex, age, health condition etc.). First, Igf1 was identified as an osteoblast lineage cell-secreted protein that induces neurite-like structures in cultured cells. Next, to study the physiological effect of Igf1, a genetically-modified mouse that do not produce Igf1 in osteoblasts was generated. Furthermore, a method to estimate bone innervation using mice that express fluorescent proteins in neurons was established. Further studies combining the Igf1 conditional knockout mice and the neuron-labeled mice are required to examine whether the loss of osteoblast-derived Igf1 affects bone innervation.

Free Research Field

骨代謝