2016 Fiscal Year Final Research Report
Analysis of the molecular pathology of frequently-accompanied pulmonary cancer in fibrotic lung
| Project/Area Number |
26860185
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Maruyama Junichi 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (30723639)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 肺線維症 / 肺癌 / DNA損傷修復 |
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| Outline of Final Research Achievements |
The molecular mechanism how idiopathic pulmonary fibrosis (IPF) is often accompanied by lung cancer is not fully understood. To address this question, I re-analyzed the GEO gene expression data obtained from IPF lung samples and identified DCLK1 as an up-regulated gene in the IPF lung. DCLK1 has been reported as a marker gene of cancer stem cells. I revealed that DCLK1 suppresses the activity of DNA repairing system and that DCLK1 protein expression level is up-regulated by the treatment of macrophage-like cell-conditioned medium. Taken together, it is suggested that the up-regulation of DCLK1 protein amount in the lung facilitates tumorigenesis and that this up-regulation can be promoted by the accumulation of macrophage cells in the lung.
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| Free Research Field |
医歯薬学
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