2017 Fiscal Year Final Research Report
Elucidation of molecular mechanisms regulating organ size and shape by using medaka
| Project/Area Number |
26860197
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Keio University (2016-2017)
Nagahama Institute of Bio-Science and Technology (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | メダカ / organogenesis / asymmetric cell division / novel gene / transmembrane protein |
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| Outline of Final Research Achievements |
We studied functions of TMEM141 that is a candidate gene from our screening study, on cellular and organism level by using mammalian cells and medaka. Subsequently, our data suggest the possibilities that the novel vesicular membrane protein, TMEM141 plays important roles in cell proliferation and maintenance of cancer stem cells. Additionally, some peptides designed based on the deduced amino acid sequence of TMEM141 inhibited proliferation in several human cancer cell lines. The knowledges obtained from the project provide the important insights not only into aspects of vertebrate organogenesis, but also into aspects of medicinal development based on novel concepts targeting cancer stem cells.
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| Free Research Field |
発生生物学・細胞生物学
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