Identification of a homeostatic factor which restores age-related dysfunctions of mesenchymal stem/stromal cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860200
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Oishi-Ohno Michiko 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 (80454875)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 間葉系幹細胞 / 幹細胞老化 / 分泌因子 / T細胞分化 / 免疫老化

Outline of Final Research Achievements

Age-related tissue stem cell dysfunctions should contribute to the disruption of tissue homeostasis and subsequent pathologies. It has been reported that some kind of systemic factors in young mice have effects to ameliorate age-related inefficient muscle repair due to restoration of regenerative capacity of aged muscle satellite cells. Some of other tissue stem/progenitor cells also restored proliferation in heterochronically connected old mice. However, little is known about the homeostatic factors and the mechanisms underlying its regenerative effects.
Recently, we identified Gdf6/Bmp13 as a homeostatic factor derived from young mesenchymal stem/stromal cells (MSCs). Administration of Gdf6 was restored the muscle wound healing and was increased neural precursor cells in a wide range from the subventricular zone to the striatum than control aged mice.

Free Research Field

医歯薬学